Prion-mediated neurodegeneration is associated with early impairment of the ubiquitin–proteasome system

Prion diseases are a group of fatal neurodegenerative disorders characterised by the accumulation of misfolded prion protein (PrP(Sc)) in the brain. The critical relationship between aberrant protein misfolding and neurotoxicity currently remains unclear. The accumulation of aggregation-prone protei...

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Dades bibliogràfiques
Publicat a:Acta Neuropathol
Autors principals: McKinnon, Chris, Goold, Rob, Andre, Ralph, Devoy, Anny, Ortega, Zaira, Moonga, Julie, Linehan, Jacqueline M., Brandner, Sebastian, Lucas, José J., Collinge, John, Tabrizi, Sarah J.
Format: Artigo
Idioma:Inglês
Publicat: Springer Berlin Heidelberg 2015
Matèries:
Original Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4752964/
https://ncbi.nlm.nih.gov/pubmed/26646779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-015-1508-y
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