Prion-mediated neurodegeneration is associated with early impairment of the ubiquitin–proteasome system

Prion diseases are a group of fatal neurodegenerative disorders characterised by the accumulation of misfolded prion protein (PrP(Sc)) in the brain. The critical relationship between aberrant protein misfolding and neurotoxicity currently remains unclear. The accumulation of aggregation-prone protei...

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Vydáno v:Acta Neuropathol
Hlavní autoři: McKinnon, Chris, Goold, Rob, Andre, Ralph, Devoy, Anny, Ortega, Zaira, Moonga, Julie, Linehan, Jacqueline M., Brandner, Sebastian, Lucas, José J., Collinge, John, Tabrizi, Sarah J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Berlin Heidelberg 2015
Témata:
Original Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4752964/
https://ncbi.nlm.nih.gov/pubmed/26646779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-015-1508-y
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