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Prion degradation pathways: Potential for therapeutic intervention

Prion diseases are fatal neurodegenerative disorders. Pathology is closely linked to the misfolding of native cellular PrP(C) into the disease-associated form PrP(Sc) that accumulates in the brain as disease progresses. Although treatments have yet to be developed, strategies aimed at stimulating th...

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Detalhes bibliográficos
Publicado no:Mol Cell Neurosci
Main Authors: Goold, Rob, McKinnon, Chris, Tabrizi, Sarah J.
Formato: Artigo
Idioma:Inglês
Publicado em: Academic Press 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4503822/
https://ncbi.nlm.nih.gov/pubmed/25584786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2014.12.009
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