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Ubiquitin–proteasome system involvement in Huntington’s disease
Huntington’s disease (HD) is a genetic autosomal dominant neurodegenerative disease caused by the expansion of a CAG repeat in the huntingtin (htt) gene. This triplet expansion encodes a polyglutamine stretch (polyQ) in the N-terminus of the high molecular weight (348-kDa) and ubiquitously expressed...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Frontiers Media S.A.
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4179678/ https://ncbi.nlm.nih.gov/pubmed/25324717 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2014.00077 |
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