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Ubiquitin/proteasome pathway impairment in neurodegeneration: therapeutic implications

The ubiquitin/proteasome pathway is the major proteolytic quality control system in cells. In this review we discuss the impact of a deregulation of this pathway on neuronal function and its causal relationship to the intracellular deposition of ubiquitin protein conjugates in pathological inclusion...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Huang, Qian, Figueiredo-Pereira, Maria E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2908192/
https://ncbi.nlm.nih.gov/pubmed/20131003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10495-010-0466-z
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