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Ubiquitin/proteasome pathway impairment in neurodegeneration: therapeutic implications
The ubiquitin/proteasome pathway is the major proteolytic quality control system in cells. In this review we discuss the impact of a deregulation of this pathway on neuronal function and its causal relationship to the intracellular deposition of ubiquitin protein conjugates in pathological inclusion...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2908192/ https://ncbi.nlm.nih.gov/pubmed/20131003 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10495-010-0466-z |
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