Prion-mediated neurodegeneration is associated with early impairment of the ubiquitin–proteasome system

Prion diseases are a group of fatal neurodegenerative disorders characterised by the accumulation of misfolded prion protein (PrP(Sc)) in the brain. The critical relationship between aberrant protein misfolding and neurotoxicity currently remains unclear. The accumulation of aggregation-prone protei...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: McKinnon, Chris, Goold, Rob, Andre, Ralph, Devoy, Anny, Ortega, Zaira, Moonga, Julie, Linehan, Jacqueline M., Brandner, Sebastian, Lucas, José J., Collinge, John, Tabrizi, Sarah J.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2015
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4752964/
https://ncbi.nlm.nih.gov/pubmed/26646779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-015-1508-y
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