Precision Tumor Recognition by T Cells With Combinatorial Antigen Sensing Circuits

T cells can be re-directed to kill cancer cells using chimeric antigen receptors (CARs) or T cell receptors (TCRs). This approach, however, is constrained by the rarity of tumor-specific single antigens. Targeting antigens also found on bystander tissues can cause life-threatening adverse effects. A...

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Vydáno v:Cell
Hlavní autoři: Roybal, Kole T., Rupp, Levi J., Morsut, Leonardo, Walker, Whitney J., McNally, Krista A., Park, Jason S., Lim, Wendell A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4752902/
https://ncbi.nlm.nih.gov/pubmed/26830879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.01.011
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