IMMU-33. MULTI-ANTIGEN RECOGNITION CIRCUITS OVERCOME CHALLENGES OF SPECIFICITY, HETEROGENEITY, AND DURABILITY IN T-CELL THERAPY FOR GLIOBLASTOMA

Treatment of solid cancers with chimeric antigen receptor (CAR) T-cells is challenging because of a lack of target antigens that are both tumor-specific and homogenously expressed. While epidermal growth factor receptor (EGFR)vIII represents a glioblastoma (GBM)-specific antigen, its expression is h...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Neuro Oncol
Hlavní autoři: Watchmaker, Payal, Choe, Joseph, Simic, Milos, Gilbert, Ryan, li, Aileen, Krasnow, Nira, Carrera, Diego, Yu, Wei, Downey, Kira, Celli, Anna, Cho, Juhyun, Briones, Jessica, Dannenfelser, Ruth, Cardarelli, Lia, Sidhu, Sachdev, Roybal, Kole, Lim, Wendell, Okada, Hideho
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2020
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7651374/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa215.463
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky