Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms

Histiocytic neoplasms are clonal, hematopoietic disorders characterized by an accumulation of abnormal, monocyte-derived dendritic cells or macrophages in Langerhans Cell (LCH) and non-Langerhans (non-LCH) histiocytoses, respectively. The discovery of BRAFV600E mutations in ~50% of these patients pr...

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Publicado en:Cancer Discov
Autores principales: Diamond, Eli L., Durham, Benjamin H., Haroche, Julien, Yao, Zhan, Ma, Jing, Parikh, Sameer A., Wang, Zhaoming, Choi, John, Kim, Eunhee, Cohen-Aubart, Fleur, Lee, Stanley Chun-Wei, Gao, Yijun, Micol, Jean-Baptiste, Campbell, Patrick, Walsh, Michael P., Sylvester, Brooke, Dolgalev, Igor, Aminova, Olga, Heguy, Adriana, Zappile, Paul, Nakitandwe, Joy, Ganzel, Chezi, Dalton, James D., Ellison, David W., Estrada-Veras, Juvianee, Lacouture, Mario, Gahl, William A., Stephens, Philip J., Miller, Vincent A., Ross, Jeffrey S., Ali, Siraj M., Briggs, Samuel R., Fasan, Omotayo, Block, Jared, Héritier, Sebastien, Donadieu, Jean, Solit, David B., Hyman, David M., Baselga, Jose, Janku, Filip, Taylor, Barry S., Park, Christopher Y., Amoura, Zahir, Dogan, Ahmet, Emile, Jean-Francois, Rosen, Neal, Gruber, Tanja A., Abdel-Wahab, Omar
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4744547/
https://ncbi.nlm.nih.gov/pubmed/26566875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-15-0913
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