Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms

Histiocytic neoplasms are clonal, hematopoietic disorders characterized by an accumulation of abnormal, monocyte-derived dendritic cells or macrophages in Langerhans Cell (LCH) and non-Langerhans (non-LCH) histiocytoses, respectively. The discovery of BRAFV600E mutations in ~50% of these patients pr...

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Pubblicato in:Cancer Discov
Autori principali: Diamond, Eli L., Durham, Benjamin H., Haroche, Julien, Yao, Zhan, Ma, Jing, Parikh, Sameer A., Wang, Zhaoming, Choi, John, Kim, Eunhee, Cohen-Aubart, Fleur, Lee, Stanley Chun-Wei, Gao, Yijun, Micol, Jean-Baptiste, Campbell, Patrick, Walsh, Michael P., Sylvester, Brooke, Dolgalev, Igor, Aminova, Olga, Heguy, Adriana, Zappile, Paul, Nakitandwe, Joy, Ganzel, Chezi, Dalton, James D., Ellison, David W., Estrada-Veras, Juvianee, Lacouture, Mario, Gahl, William A., Stephens, Philip J., Miller, Vincent A., Ross, Jeffrey S., Ali, Siraj M., Briggs, Samuel R., Fasan, Omotayo, Block, Jared, Héritier, Sebastien, Donadieu, Jean, Solit, David B., Hyman, David M., Baselga, Jose, Janku, Filip, Taylor, Barry S., Park, Christopher Y., Amoura, Zahir, Dogan, Ahmet, Emile, Jean-Francois, Rosen, Neal, Gruber, Tanja A., Abdel-Wahab, Omar
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4744547/
https://ncbi.nlm.nih.gov/pubmed/26566875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-15-0913
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