Functional evidence for derivation of systemic histiocytic neoplasms from hematopoietic stem/progenitor cells

Langerhans cell histiocytosis (LCH) and the non-LCH neoplasm Erdheim-Chester disease (ECD) are heterogeneous neoplastic disorders marked by infiltration of pathologic macrophage-, dendritic cell–, or monocyte-derived cells in tissues driven by recurrent mutations activating MAPK signaling. Although...

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Bibliographic Details
Published in:Blood
Main Authors: Durham, Benjamin H., Roos-Weil, Damien, Baillou, Claude, Cohen-Aubart, Fleur, Yoshimi, Akihide, Miyara, Makoto, Papo, Matthias, Hélias-Rodzewicz, Zofia, Terrones, Nathalie, Ozkaya, Neval, Dogan, Ahmet, Rampal, Raajit, Urbain, Fanny, Le Fèvre, Lucie, Diamond, Eli L., Park, Christopher Y., Papo, Thomas, Charlotte, Frédéric, Gorochov, Guy, Taly, Valérie, Bernard, Olivier A., Amoura, Zahir, Abdel-Wahab, Omar, Lemoine, François M., Haroche, Julien, Emile, Jean-François
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2017
Subjects:
Myeloid Neoplasia
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5510787/
https://ncbi.nlm.nih.gov/pubmed/28566492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-12-757377
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