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Antisense-oligonucleotide-directed inhibition of nonsense-mediated mRNA decay
Nonsense-mediated mRNA decay (NMD) is a cellular quality-control mechanism that is thought to exacerbate the phenotype of certain pathogenic nonsense mutations by preventing the expression of semi-functional proteins. NMD also limits the efficacy of read-through compound (RTC)-based therapies. Here,...
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| Publicado no: | Nat Biotechnol |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4744113/ https://ncbi.nlm.nih.gov/pubmed/26655495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3427 |
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