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Mechanism of Nonsense-Mediated mRNA Decay Stimulation by Splicing Factor SRSF1
The splicing factor SRSF1 promotes nonsense-mediated mRNA decay (NMD), a quality control mechanism that degrades mRNAs with premature termination codons (PTCs). Here we show that transcript-bound SRSF1 increases the binding of NMD factor UPF1 to mRNAs while in, or associated with, the nucleus, bypas...
Gorde:
| Argitaratua izan da: | Cell Rep |
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| Egile Nagusiak: | , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2018
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5999336/ https://ncbi.nlm.nih.gov/pubmed/29768215 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.04.039 |
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