Mechanism of Nonsense-Mediated mRNA Decay Stimulation by Splicing Factor SRSF1

The splicing factor SRSF1 promotes nonsense-mediated mRNA decay (NMD), a quality control mechanism that degrades mRNAs with premature termination codons (PTCs). Here we show that transcript-bound SRSF1 increases the binding of NMD factor UPF1 to mRNAs while in, or associated with, the nucleus, bypas...

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Udgivet i:Cell Rep
Main Authors: Aznarez, Isabel, Nomakuchi, Tomoki T., Tetenbaum-Novatt, Jaclyn, Rahman, Mohammad Alinoor, Fregoso, Oliver, Rees, Holly, Krainer, Adrian R.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5999336/
https://ncbi.nlm.nih.gov/pubmed/29768215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.04.039
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