Clinical Applications of Single-Stranded Oligonucleotides: Current Landscape of Approved and In-Development Therapeutics

por Scharner, Juergen, Aznarez, Isabel
Publicado en Mol Ther (2021)

Antisense-oligonucleotide-directed inhibition of nonsense-mediated mRNA decay

por Nomakuchi, Tomoki T., Rigo, Frank, Aznarez, Isabel, Krainer, Adrian R.
Publicado en Nat Biotechnol (2015)

Exon skipping through the creation of a putative exonic splicing silencer as a consequence of the cystic fibrosis mutation R553X

por Aznarez, Isabel, Zielenski, Julian, Rommens, Johanna M, Blencowe, Benjamin J, Tsui, Lap‐Chee
Publicado 2007

Mechanism of Nonsense-Mediated mRNA Decay Stimulation by Splicing Factor SRSF1

por Aznarez, Isabel, Nomakuchi, Tomoki T., Tetenbaum-Novatt, Jaclyn, Rahman, Mohammad Alinoor, Fregoso, Oliver, Rees, Holly, Krainer, Adrian R.
Publicado en Cell Rep (2018)

A systematic analysis of intronic sequences downstream of 5′ splice sites reveals a widespread role for U-rich motifs and TIA1/TIAL1 proteins in alternative splicing regulation

por Aznarez, Isabel, Barash, Yoseph, Shai, Ofer, He, David, Zielenski, Julian, Tsui, Lap-Chee, Parkinson, John, Frey, Brendan J., Rommens, Johanna M., Blencowe, Benjamin J.
Publicado 2008

Antisense oligonucleotide modulation of non-productive alternative splicing upregulates gene expression

por Lim, Kian Huat, Han, Zhou, Jeon, Hyun Yong, Kach, Jacob, Jing, Enxuan, Weyn-Vanhentenryck, Sebastien, Downs, Mikaela, Corrionero, Anna, Oh, Raymond, Scharner, Juergen, Venkatesh, Aditya, Ji, Sophina, Liau, Gene, Ticho, Barry, Nash, Huw, Aznarez, Isabel
Publicado en Nat Commun (2020)