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Inhibition of Nonsense-Mediated mRNA Decay by Antisense Morpholino Oligonucleotides Restores Functional Expression of hERG Nonsense and Frameshift Mutations in Long QT Syndrome
Mutations in the human ether-a-go-go-related gene (hERG) cause long QT syndrome type 2 (LQT2). We previously described a homozygous LQT2 nonsense mutation Q1070X in which the mutant mRNA is degraded by nonsense-mediated mRNA decay (NMD) leading to a severe clinical phenotype. The degradation of the...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3049309/ https://ncbi.nlm.nih.gov/pubmed/21035456 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2010.10.022 |
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