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Upregulation of Functional Kv11.1 Isoform Expression by Inhibition of Intronic Polyadenylation with Antisense Morpholino Oligonucleotides

The KCNH2 gene encodes the Kv11.1 potassium channel that conducts the rapidly activating delayed rectifier current in the heart. KCNH2 pre-mRNA undergoes alternative processing; intron 9 splicing leads to the formation of a functional, full-length Kv11.1a isoform, while polyadenylation within intron...

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Dades bibliogràfiques
Publicat a:J Mol Cell Cardiol
Autors principals: Gong, Qiuming, Stump, Matthew R., Zhou, Zhengfeng
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4250341/
https://ncbi.nlm.nih.gov/pubmed/25128783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2014.08.007
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