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Upregulation of Functional Kv11.1 Isoform Expression by Inhibition of Intronic Polyadenylation with Antisense Morpholino Oligonucleotides

The KCNH2 gene encodes the Kv11.1 potassium channel that conducts the rapidly activating delayed rectifier current in the heart. KCNH2 pre-mRNA undergoes alternative processing; intron 9 splicing leads to the formation of a functional, full-length Kv11.1a isoform, while polyadenylation within intron...

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Detalles Bibliográficos
Publicado en:J Mol Cell Cardiol
Main Authors: Gong, Qiuming, Stump, Matthew R., Zhou, Zhengfeng
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4250341/
https://ncbi.nlm.nih.gov/pubmed/25128783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2014.08.007
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