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Position of Premature Termination Codons Determines Susceptibility of hERG mutations to Nonsense-Mediated mRNA Decay in Long QT Syndrome

The degradation of human ether-a-go-go-related gene (hERG, KCNH2) transcripts containing premature termination codon (PTC) mutations by nonsense-mediated mRNA decay (NMD) is an important mechanism of long QT syndrome type 2 (LQT2). The mechanisms governing the recognition of PTC-containing hERG tran...

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Detalhes bibliográficos
Main Authors: Gong, Qiuming, Stump, Matthew R., Zhou, Zhengfeng
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4142825/
https://ncbi.nlm.nih.gov/pubmed/24530480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gene.2014.02.012
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