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Nonsense-mediated decay as a terminating mechanism for antisense oligonucleotides
Antisense oligonucleotides (ASOs) are synthetic oligonucleotides that alter expression of disease-associated transcripts via Watson–Crick hybridization. ASOs that function through RNase H or the RNA-induced silencing complex (RISC) result in enzymatic degradation of target RNA. ASOs designed to ster...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4027159/ https://ncbi.nlm.nih.gov/pubmed/24589581 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku184 |
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