Nonsense-mediated decay as a terminating mechanism for antisense oligonucleotides

Antisense oligonucleotides (ASOs) are synthetic oligonucleotides that alter expression of disease-associated transcripts via Watson–Crick hybridization. ASOs that function through RNase H or the RNA-induced silencing complex (RISC) result in enzymatic degradation of target RNA. ASOs designed to ster...

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Sonraí Bibleagrafaíochta
Main Authors: Ward, Amanda J., Norrbom, Michaela, Chun, Seung, Bennett, C. Frank, Rigo, Frank
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2014
Ábhair:
RNA
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4027159/
https://ncbi.nlm.nih.gov/pubmed/24589581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku184
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