Antisense Oligonucleotides Modulating Activation of a Nonsense-Mediated RNA Decay Switch Exon in the ATM Gene

ATM (ataxia-telangiectasia, mutated) is an important cancer susceptibility gene that encodes a key apical kinase in the DNA damage response pathway. ATM mutations in the germ line result in ataxia-telangiectasia (A-T), a rare genetic syndrome associated with hypersensitivity to double-strand DNA bre...

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發表在:Nucleic Acid Ther
Main Authors: Kralovicova, Jana, Moreno, Pedro M.D., Cross, Nicholas C.P., Pêgo, Ana Paula, Vorechovsky, Igor
格式: Artigo
語言:Inglês
出版: Mary Ann Liebert, Inc. 2016
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Original Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5105335/
https://ncbi.nlm.nih.gov/pubmed/27658045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2016.0635
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