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Exon-centric regulation of ATM expression is population-dependent and amenable to antisense modification by pseudoexon targeting
ATM is an important cancer susceptibility gene that encodes a critical apical kinase of the DNA damage response (DDR) pathway. We show that a key nonsense-mediated RNA decay switch exon (NSE) in ATM is repressed by U2AF, PUF60 and hnRNPA1. The NSE activation was haplotype-specific and was most promo...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4702124/ https://ncbi.nlm.nih.gov/pubmed/26732650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep18741 |
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