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Transcriptomic Determinants of Scrapie Prion Propagation in Cultured Ovine Microglia

Susceptibility to infection by prions is highly dependent on the amino acid sequence and host expression of the cellular prion protein (PrP(C)); however, cellular expression of a genetically susceptible PrP(C) is insufficient. As an example, it has been shown in cultured cells that permissive and re...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Muñoz-Gutiérrez, Juan F., Aguilar Pierlé, Sebastián, Schneider, David A., Baszler, Timothy V., Stanton, James B.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2016
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4726464/
https://ncbi.nlm.nih.gov/pubmed/26807844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0147727
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