Discovery of a Novel, Monocationic, Small-Molecule Inhibitor of Scrapie Prion Accumulation in Cultured Sheep Microglia and Rov Cells

Prion diseases, including sheep scrapie, are neurodegenerative diseases with the fundamental pathogenesis involving conversion of normal cellular prion protein (PrP(C)) to disease-associated prion protein (PrP(Sc)). Chemical inhibition of prion accumulation is widely investigated, often using rodent...

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Detalhes bibliográficos
Main Authors: Stanton, James B., Schneider, David A., Dinkel, Kelcey D., Balmer, Bethany F., Baszler, Timothy V., Mathison, Bruce A., Boykin, David W., Kumar, Arvind
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511409/
https://ncbi.nlm.nih.gov/pubmed/23226483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051173
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