Discovery of a Novel, Monocationic, Small-Molecule Inhibitor of Scrapie Prion Accumulation in Cultured Sheep Microglia and Rov Cells

Prion diseases, including sheep scrapie, are neurodegenerative diseases with the fundamental pathogenesis involving conversion of normal cellular prion protein (PrP(C)) to disease-associated prion protein (PrP(Sc)). Chemical inhibition of prion accumulation is widely investigated, often using rodent...

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Detaylı Bibliyografya
Asıl Yazarlar: Stanton, James B., Schneider, David A., Dinkel, Kelcey D., Balmer, Bethany F., Baszler, Timothy V., Mathison, Bruce A., Boykin, David W., Kumar, Arvind
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2012
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511409/
https://ncbi.nlm.nih.gov/pubmed/23226483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051173
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