Discovery of a Novel, Monocationic, Small-Molecule Inhibitor of Scrapie Prion Accumulation in Cultured Sheep Microglia and Rov Cells

Prion diseases, including sheep scrapie, are neurodegenerative diseases with the fundamental pathogenesis involving conversion of normal cellular prion protein (PrP(C)) to disease-associated prion protein (PrP(Sc)). Chemical inhibition of prion accumulation is widely investigated, often using rodent...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Stanton, James B., Schneider, David A., Dinkel, Kelcey D., Balmer, Bethany F., Baszler, Timothy V., Mathison, Bruce A., Boykin, David W., Kumar, Arvind
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2012
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511409/
https://ncbi.nlm.nih.gov/pubmed/23226483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051173
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