Discovery of a Novel, Monocationic, Small-Molecule Inhibitor of Scrapie Prion Accumulation in Cultured Sheep Microglia and Rov Cells

Prion diseases, including sheep scrapie, are neurodegenerative diseases with the fundamental pathogenesis involving conversion of normal cellular prion protein (PrP(C)) to disease-associated prion protein (PrP(Sc)). Chemical inhibition of prion accumulation is widely investigated, often using rodent...

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Autori principali: Stanton, James B., Schneider, David A., Dinkel, Kelcey D., Balmer, Bethany F., Baszler, Timothy V., Mathison, Bruce A., Boykin, David W., Kumar, Arvind
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3511409/
https://ncbi.nlm.nih.gov/pubmed/23226483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0051173
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