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Entrapment of a Histone Tail by a DNA Lesion in a Nucleosome Suggests the Lesion Impacts Epigenetic Marking: A Molecular Dynamics Study
[Image: see text] Errors in epigenetic markings are associated with human diseases, including cancer. We have used molecular dynamics simulations of a nucleosome containing the 10S (+)-trans-anti-B[a]P-N(2)-dG lesion, derived from the environmental pro-carcinogen benzo[a]pyrene, to elucidate the imp...
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| Pubblicato in: | Biochemistry |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American
Chemical Society
2015
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4721520/ https://ncbi.nlm.nih.gov/pubmed/26709619 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b01166 |
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