Maturation and diversity of the VRC01-antibody lineage over 15 years of chronic HIV-1 infection

HIV-1-neutralizing antibodies develop in most HIV-1-infected individuals, although highly effective antibodies are generally observed only after years of chronic infection. Here we characterize the rate of maturation and extent of diversity for the lineage that produced the broadly neutralizing anti...

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Pubblicato in:Cell
Autori principali: Wu, Xueling, Zhang, Zhenhai, Schramm, Chaim A., Joyce, M. Gordon, Do Kwon, Young, Zhou, Tongqing, Sheng, Zizhang, Zhang, Baoshan, O'Dell, Sijy, McKee, Krisha, Georgiev, Ivelin S., Chuang, Gwo-Yu, Longo, Nancy S., Lynch, Rebecca M., Saunders, Kevin O., Soto, Cinque, Srivatsan, Sanjay, Yang, Yongping, Bailer, Robert T., Louder, Mark K., Mullikin, James C., Connors, Mark, Kwong, Peter D., Mascola, John R., Shapiro, Lawrence
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4706178/
https://ncbi.nlm.nih.gov/pubmed/25865483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.03.004
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