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Iterative Tyrosine Phosphorylation Controls Non-canonical Domain Utilization in Crk
Crk, the prototypical member of a class of SH2 and SH3 domain-containing proteins that controls the coordinated assembly of signaling complexes, is regulated by phosphorylation of Y221 in the linker region, which forms an intramolecular SH2-pY221 auto-clamp to interrupt SH2-SH3N signaling. Here, we...
में बचाया:
| में प्रकाशित: | Oncogene |
|---|---|
| मुख्य लेखकों: | , , , , , , , , , , , , |
| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
2014
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4706174/ https://ncbi.nlm.nih.gov/pubmed/25381819 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.361 |
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