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Domain organization differences explain Bcr-Abl’s preference for CrkL over CrkII
CrkL is a key signaling protein that mediates the leukemogenic activity of Bcr-Abl. CrkL is thought to adopt a structure that is similar to that of its CrkII homolog. The two proteins share high sequence identity and indistinguishable ligand binding preferences; yet they have distinct physiological...
Tallennettuna:
| Päätekijät: | , , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2012
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3423979/ https://ncbi.nlm.nih.gov/pubmed/22581121 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.954 |
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