Iterative Tyrosine Phosphorylation Controls Non-canonical Domain Utilization in Crk

Crk, the prototypical member of a class of SH2 and SH3 domain-containing proteins that controls the coordinated assembly of signaling complexes, is regulated by phosphorylation of Y221 in the linker region, which forms an intramolecular SH2-pY221 auto-clamp to interrupt SH2-SH3N signaling. Here, we...

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Veröffentlicht in:Oncogene
Hauptverfasser: Sriram, Ganapathy, Jankowski, Wojciech, Kasikara, Canan, Reichman, Charles, Saleh, Tamjeed, Nguyen, Khanh-Quynh, Li, Jing, Hornbeck, Peter, Machida, Kazuya, Liu, Tong, Li, Hong, Kalodimos, Charalampos G., Birge, Raymond B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4706174/
https://ncbi.nlm.nih.gov/pubmed/25381819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.361
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