Phosphorylation of Crk on tyrosine 251 in the RT loop of the SH3C domain promotes Abl kinase transactivation

Here, we report the identification and characterization of a novel tyrosine phosphorylation site in the carboxy-terminal Src Homology 3 (SH3) (SH3C) domain of the Crk adaptor protein. Y251 is located in the highly conserved RT loop structure of the SH3C, a region of Crk involved in the allosteric re...

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Autori principali: Sriram, G, Reichman, C, Tunceroglu, A, Kaushal, N, Saleh, T, Machida, K, Mayer, B, Ge, Q, Li, J, Hornbeck, P, Kalodimos, CG, Birge, RB
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3311107/
https://ncbi.nlm.nih.gov/pubmed/21602891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.170
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