Cyclophilin A promotes cell migration via the Abl-Crk signaling pathway

Cyclophilin A (CypA) is over-expressed in a number of human cancer types, but the mechanisms by which CypA promotes oncogenic properties of cells are not understood. Here we demonstrate that CypA binds to and prevents the CrkII adaptor protein from switching to the inhibited state. CrkII is involved...

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Detaylı Bibliyografya
Yayımlandı:Nat Chem Biol
Asıl Yazarlar: Saleh, Tamjeed, Jankowski, Wojciech, Sriram, Ganapathy, Rossi, Paolo, Shah, Shreyas, Lee, Ki-Bum, Cruz, Lissette Alicia, Rodriguez, Alexis J., Birge, Raymond B., Kalodimos, Charalampos G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4718742/
https://ncbi.nlm.nih.gov/pubmed/26656091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1981
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