Cyclophilin A promotes cell migration via the Abl-Crk signaling pathway

Cyclophilin A (CypA) is over-expressed in a number of human cancer types, but the mechanisms by which CypA promotes oncogenic properties of cells are not understood. Here we demonstrate that CypA binds to and prevents the CrkII adaptor protein from switching to the inhibited state. CrkII is involved...

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Pubblicato in:Nat Chem Biol
Autori principali: Saleh, Tamjeed, Jankowski, Wojciech, Sriram, Ganapathy, Rossi, Paolo, Shah, Shreyas, Lee, Ki-Bum, Cruz, Lissette Alicia, Rodriguez, Alexis J., Birge, Raymond B., Kalodimos, Charalampos G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4718742/
https://ncbi.nlm.nih.gov/pubmed/26656091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1981
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