Crystal structure, conformational fixation, and entry-related interactions of mature ligand-free HIV-1 Env

As the sole viral antigen on the HIV-1-virion surface, trimeric Env is a focus of vaccine efforts. Here we present the structure of the ligand-free HIV-1-Env trimer, fix its conformation, and determine its receptor interactions. Epitope analyses revealed trimeric ligand-free Env to be structurally c...

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Publicado no:Nat Struct Mol Biol
Main Authors: Kwon, Young Do, Pancera, Marie, Acharya, Priyamvada, Georgiev, Ivelin S., Crooks, Emma T., Gorman, Jason, Joyce, M. Gordon, Guttman, Miklos, Ma, Xiaochu, Narpala, Sandeep, Soto, Cinque, Terry, Daniel S., Yang, Yongping, Zhou, Tongqing, Ahlsen, Goran, Bailer, Robert T., Chambers, Michael, Chuang, Gwo-Yu, Doria-Rose, Nicole A., Druz, Aliaksandr, Hallen, Mark A., Harned, Adam, Kirys, Tatsiana, Louder, Mark K., O’Dell, Sijy, Ofek, Gilad, Osawa, Keiko, Prabhakaran, Madhu, Sastry, Mallika, Stewart-Jones, Guillaume B.E., Stuckey, Jonathan, Thomas, Paul V., Tittley, Tishina, Williams, Constance, Zhang, Baoshan, Zhao, Hong, Zhou, Zhou, Donald, Bruce R., Lee, Lawrence K., Zolla-Pazner, Susan, Baxa, Ulrich, Schön, Arne, Freire, Ernesto, Shapiro, Lawrence, Lee, Kelly K., Arthos, James, Munro, James B., Blanchard, Scott C., Mothes, Walther, Binley, James M., McDermott, Adrian B., Mascola, John R., Kwong, Peter D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4706170/
https://ncbi.nlm.nih.gov/pubmed/26098315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3051
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