Ligand-Based Discovery of a New Scaffold for Allosteric Modulation of the μ-Opioid Receptor

With the hope of discovering effective analgesics with fewer side effects, attention has recently shifted to allosteric modulators of the opioid receptors. In the past two years, the first chemotypes of positive or silent allosteric modulators (PAMs or SAMs, respectively) of μ- and δ-opioid receptor...

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Udgivet i:J Chem Inf Model
Main Authors: Bisignano, Paola, Burford, Neil T., Shang, Yi, Marlow, Brennica, Livingston, Kathryn E., Fenton, Abigail M., Rockwell, Kristin, Budenholzer, Lauren, Traynor, John R., Gerritz, Samuel W., Alt, Andrew, Filizola, Marta
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703110/
https://ncbi.nlm.nih.gov/pubmed/26347990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jcim.5b00388
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