Ligand-Based Discovery of a New Scaffold for Allosteric Modulation of the μ-Opioid Receptor

With the hope of discovering effective analgesics with fewer side effects, attention has recently shifted to allosteric modulators of the opioid receptors. In the past two years, the first chemotypes of positive or silent allosteric modulators (PAMs or SAMs, respectively) of μ- and δ-opioid receptor...

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Detalhes bibliográficos
Publicado no:J Chem Inf Model
Main Authors: Bisignano, Paola, Burford, Neil T., Shang, Yi, Marlow, Brennica, Livingston, Kathryn E., Fenton, Abigail M., Rockwell, Kristin, Budenholzer, Lauren, Traynor, John R., Gerritz, Samuel W., Alt, Andrew, Filizola, Marta
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703110/
https://ncbi.nlm.nih.gov/pubmed/26347990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jcim.5b00388
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