Ligand-Based Discovery of a New Scaffold for Allosteric Modulation of the μ-Opioid Receptor

With the hope of discovering effective analgesics with fewer side effects, attention has recently shifted to allosteric modulators of the opioid receptors. In the past two years, the first chemotypes of positive or silent allosteric modulators (PAMs or SAMs, respectively) of μ- and δ-opioid receptor...

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Veröffentlicht in:J Chem Inf Model
Hauptverfasser: Bisignano, Paola, Burford, Neil T., Shang, Yi, Marlow, Brennica, Livingston, Kathryn E., Fenton, Abigail M., Rockwell, Kristin, Budenholzer, Lauren, Traynor, John R., Gerritz, Samuel W., Alt, Andrew, Filizola, Marta
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703110/
https://ncbi.nlm.nih.gov/pubmed/26347990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jcim.5b00388
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