Discovery, Synthesis, and Molecular Pharmacology of Selective Positive Allosteric Modulators of the δ-Opioid Receptor

Allosteric modulators of G protein-coupled receptors (GPCRs) have a number of potential advantages compared to agonists or antagonists that bind to the orthosteric site of the receptor. These include the potential or receptor selectivity, maintenance of the temporal and spatial fidelity of signaling...

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Publicado en:J Med Chem
Main Authors: Burford, Neil T., Livingston, Kathryn E., Canals, Meritxell, Ryan, Molly R., Budenholzer, Lauren M. L., Han, Ying, Shang, Yi, Herbst, John J., O'Connell, Jonathan, Banks, Martyn, Zhang, Litao, Filizola, Marta, Bassoni, Daniel L., Wehrman, Tom S., Christopoulos, Arthur, Traynor, John R., Gerritz, Samuel W., Alt, Andrew
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4703104/
https://ncbi.nlm.nih.gov/pubmed/25901762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.5b00007
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