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Discovery of positive allosteric modulators and silent allosteric modulators of the μ-opioid receptor
μ-Opioid receptors are among the most studied G protein-coupled receptors because of the therapeutic value of agonists, such as morphine, that are used to treat chronic pain. However, these drugs have significant side effects, such as respiratory suppression, constipation, allodynia, tolerance, and...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3696790/ https://ncbi.nlm.nih.gov/pubmed/23754417 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1300393110 |
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