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Synthetic CRISPR RNA-Cas9–guided genome editing in human cells
Genome editing with the clustered, regularly interspaced, short palindromic repeats (CRISPR)-Cas9 nuclease system is a powerful technology for manipulating genomes, including introduction of gene disruptions or corrections. Here we develop a chemically modified, 29-nucleotide synthetic CRISPR RNA (s...
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| 發表在: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4697396/ https://ncbi.nlm.nih.gov/pubmed/26589814 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1520883112 |
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