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Identification and Characterization of Novel Broad-Spectrum Inhibitors of the Flavivirus Methyltransferase
Flavivirus methyltransferase (MTase) is essential for viral replication. Here we report the identification of small molecules through virtual screening that putatively bind to the SAM-binding site of flavivirus MTase and inhibit its function. Six of these computationally predicted binders were ident...
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| Publicado no: | ACS Infect Dis |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4696607/ https://ncbi.nlm.nih.gov/pubmed/26726314 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.5b00070 |
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