Identification and Characterization of Novel Broad-Spectrum Inhibitors of the Flavivirus Methyltransferase

Flavivirus methyltransferase (MTase) is essential for viral replication. Here we report the identification of small molecules through virtual screening that putatively bind to the SAM-binding site of flavivirus MTase and inhibit its function. Six of these computationally predicted binders were ident...

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Gepubliceerd in:ACS Infect Dis
Hoofdauteurs: Brecher, Matthew, Chen, Hui, Li, Zhong, Banavali, Nilesh K., Jones, Susan A., Zhang, Jing, Kramer, Laura D., Li, Hongmin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4696607/
https://ncbi.nlm.nih.gov/pubmed/26726314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.5b00070
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