Novel Broad Spectrum Inhibitors Targeting the Flavivirus Methyltransferase

The flavivirus methyltransferase (MTase) is an essential enzyme that sequentially methylates the N7 and 2’-O positions of the viral RNA cap, using S-adenosyl-L-methionine (SAM) as a methyl donor. We report here that small molecule compounds, which putatively bind to the SAM-binding site of flaviviru...

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Опубликовано в: :PLoS One
Главные авторы: Brecher, Matthew, Chen, Hui, Liu, Binbin, Banavali, Nilesh K., Jones, Susan A., Zhang, Jing, Li, Zhong, Kramer, Laura D., Li, Hongmin
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2015
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4476580/
https://ncbi.nlm.nih.gov/pubmed/26098995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130062
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