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Novel Broad Spectrum Inhibitors Targeting the Flavivirus Methyltransferase
The flavivirus methyltransferase (MTase) is an essential enzyme that sequentially methylates the N7 and 2’-O positions of the viral RNA cap, using S-adenosyl-L-methionine (SAM) as a methyl donor. We report here that small molecule compounds, which putatively bind to the SAM-binding site of flaviviru...
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| Izdano u: | PLoS One |
|---|---|
| Glavni autori: | , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Public Library of Science
2015
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4476580/ https://ncbi.nlm.nih.gov/pubmed/26098995 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0130062 |
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