Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction

Recent outbreaks of Zika virus (ZIKV) highlight an urgent need for therapeutics. The protease complex NS2B-NS3 plays essential roles during flaviviral polyprotein processing, and thus represents an attractive drug target. Here, we developed a split luciferase complementation-based high-throughput sc...

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Detalhes bibliográficos
Publicado no:Cell Res
Main Authors: Li, Zhong, Brecher, Matthew, Deng, Yong-Qiang, Zhang, Jing, Sakamuru, Srilatha, Liu, Binbin, Huang, Ruili, Koetzner, Cheri A, Allen, Christina A, Jones, Susan A, Chen, Haiying, Zhang, Na-Na, Tian, Min, Gao, Fengshan, Lin, Qishan, Banavali, Nilesh, Zhou, Jia, Boles, Nathan, Xia, Menghang, Kramer, Laura D, Qin, Cheng-Feng, Li, Hongmin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5539352/
https://ncbi.nlm.nih.gov/pubmed/28685770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2017.88
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