A conformational switch high-throughput screening assay and allosteric inhibition of the flavivirus NS2B-NS3 protease

The flavivirus genome encodes a single polyprotein precursor requiring multiple cleavages by host and viral proteases in order to produce the individual proteins that constitute an infectious virion. Previous studies have revealed that the NS2B cofactor of the viral NS2B-NS3 heterocomplex protease d...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Brecher, Matthew, Li, Zhong, Liu, Binbin, Zhang, Jing, Koetzner, Cheri A., Alifarag, Adham, Jones, Susan A., Lin, Qishan, Kramer, Laura D., Li, Hongmin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5462475/
https://ncbi.nlm.nih.gov/pubmed/28542603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006411
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