A conformational switch high-throughput screening assay and allosteric inhibition of the flavivirus NS2B-NS3 protease

The flavivirus genome encodes a single polyprotein precursor requiring multiple cleavages by host and viral proteases in order to produce the individual proteins that constitute an infectious virion. Previous studies have revealed that the NS2B cofactor of the viral NS2B-NS3 heterocomplex protease d...

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Dettagli Bibliografici
Pubblicato in:PLoS Pathog
Autori principali: Brecher, Matthew, Li, Zhong, Liu, Binbin, Zhang, Jing, Koetzner, Cheri A., Alifarag, Adham, Jones, Susan A., Lin, Qishan, Kramer, Laura D., Li, Hongmin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5462475/
https://ncbi.nlm.nih.gov/pubmed/28542603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006411
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