A conformational switch high-throughput screening assay and allosteric inhibition of the flavivirus NS2B-NS3 protease

The flavivirus genome encodes a single polyprotein precursor requiring multiple cleavages by host and viral proteases in order to produce the individual proteins that constitute an infectious virion. Previous studies have revealed that the NS2B cofactor of the viral NS2B-NS3 heterocomplex protease d...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:PLoS Pathog
Autors principals: Brecher, Matthew, Li, Zhong, Liu, Binbin, Zhang, Jing, Koetzner, Cheri A., Alifarag, Adham, Jones, Susan A., Lin, Qishan, Kramer, Laura D., Li, Hongmin
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2017
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5462475/
https://ncbi.nlm.nih.gov/pubmed/28542603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1006411
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars