S-Adenosyl-Homocysteine Is a Weakly Bound Inhibitor for a Flaviviral Methyltransferase

The methyltransferase enzyme (MTase), which catalyzes the transfer of a methyl group from S-adenosyl-methionine (AdoMet) to viral RNA, and generates S-adenosyl-homocysteine (AdoHcy) as a by-product, is essential for the life cycle of many significant human pathogen flaviviruses. Here we investigated...

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Bibliographic Details
Main Authors: Chen, Hui, Zhou, Bing, Brecher, Matthew, Banavali, Nilesh, Jones, Susan A., Li, Zhong, Zhang, Jing, Nag, Dilip, Kramer, Laura D., Ghosh, Arun K., Li, Hongmin
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3793912/
https://ncbi.nlm.nih.gov/pubmed/24130807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0076900
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