טוען...
SELECTIVE INHIBITION OF THE WEST NILE VIRUS METHYLTRANSFERASE BY NUCLEOSIDE ANALOGS
The flavivirus methyltransferase (MTase) sequentially methylates the N7 and 2’-O positions of the viral RNA cap (GpppA-RNA→m(7)GpppA-RNA→m(7)GpppAm-RNA), using S-adenosyl-L-methionine (SAM) as a methyl donor. We report here the synthesis and biological evaluation of a series of novel nucleoside anal...
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| Main Authors: | , , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
2012
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3608738/ https://ncbi.nlm.nih.gov/pubmed/23267828 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2012.12.012 |
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