SELECTIVE INHIBITION OF THE WEST NILE VIRUS METHYLTRANSFERASE BY NUCLEOSIDE ANALOGS

The flavivirus methyltransferase (MTase) sequentially methylates the N7 and 2’-O positions of the viral RNA cap (GpppA-RNA→m(7)GpppA-RNA→m(7)GpppAm-RNA), using S-adenosyl-L-methionine (SAM) as a methyl donor. We report here the synthesis and biological evaluation of a series of novel nucleoside anal...

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Bibliografiset tiedot
Päätekijät: Chen, Hui, Liu, Lihui, Jones, Susan A., Banavali, Nilesh, Kass, Jorden, Li, Zhong, Zhang, Jing, Kramer, Laura D., Ghosh, Arun K., Li, Hongmin
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2012
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3608738/
https://ncbi.nlm.nih.gov/pubmed/23267828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2012.12.012
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