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Flavivirus RNA cap methyltransferase: structure, function, and inhibition
Many flaviviruses are significant human pathogens. The plus-strand RNA genome of a flavivirus contains a 5′ terminal cap 1 structure (m(7)GpppAmG). The flavivirus encodes one methyltransferase (MTase), located at the N-terminal portion of the NS5 RNA-dependent RNA polymerase (RdRp). Here we review r...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3172701/ https://ncbi.nlm.nih.gov/pubmed/21927615 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11515-010-0660-y |
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