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Flavivirus RNA cap methyltransferase: structure, function, and inhibition

Many flaviviruses are significant human pathogens. The plus-strand RNA genome of a flavivirus contains a 5′ terminal cap 1 structure (m(7)GpppAmG). The flavivirus encodes one methyltransferase (MTase), located at the N-terminal portion of the NS5 RNA-dependent RNA polymerase (RdRp). Here we review r...

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書目詳細資料
Main Authors: LIU, Lihui, DONG, Hongping, CHEN, Hui, ZHANG, Jing, LING, Hua, LI, Zhong, SHI, Pei-Yong, LI, Hongmin
格式: Artigo
語言:Inglês
出版: 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3172701/
https://ncbi.nlm.nih.gov/pubmed/21927615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11515-010-0660-y
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