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Structural and Functional Analyses of a Conserved Hydrophobic Pocket of Flavivirus Methyltransferase
The flavivirus methyltransferase (MTase) sequentially methylates the N7 and 2′-O positions of the viral RNA cap (GpppA-RNA → m(7)GpppA-RNA → m(7)GpppAm-RNA), using S-adenosyl-l-methionine (AdoMet) as a methyl donor. We report here that sinefungin (SIN), an AdoMet analog, inhibits several flaviviruse...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2952261/ https://ncbi.nlm.nih.gov/pubmed/20685660 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.129197 |
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